Understanding Endometriosis: Symptoms, Diagnosis, and Treatment Options

Endometriosis symptoms affects approximately 1 in 10 women of reproductive age—that’s roughly 176 million women worldwide. Yet, many suffer for years before diagnosis. At North Delhi Uro & Gynae Clinic, we help women understand and manage this chronic condition.

What is Endometriosis?

Endometriosis occurs when tissue similar to the uterine lining (endometrium) grows outside the uterus in other parts of the body. This tissue responds to hormonal changes, bleeds during menstruation, but has nowhere to go, causing inflammation, scarring, and pain.

Common Locations of Endometrial Tissue: – Fallopian tubes – Ovaries – Pelvic peritoneum (pelvic lining) – Bladder – Bowel – Rarely: lungs, brain, skin

Endometriosis vs. Adenomyosis

Endometriosis: – Tissue grows outside uterus – Distinct lesions/implants – More superficial – Affects fertility more commonly

Adenomyosis: – Tissue grows into uterine muscle – Diffuse involvement – Deeper penetration – Usually occurs in women >40 years

Stages of Endometriosis

Stage 1 (Minimal): – Few small lesions – No significant scarring – May have minimal symptoms

Stage 2 (Mild): – More lesions – Some adhesions forming – Mild pain possible

Stage 3 (Moderate): – Multiple lesions – Adhesions present – Ovarian involvement possible – Moderate pain likely

Stage 4 (Severe): – Extensive lesions – Dense adhesions – Ovarian involvement likely – Significant pain – Fertility often affected

Symptoms of Endometriosis

Pain Symptoms (Most Common):Dysmenorrhea: Severe menstrual cramps – Chronic Pelvic Pain: Between periods – Dyspareunia: Pain during intercourse – Dyschezia: Pain during bowel movements – Dysuria: Pain during urination (if bladder involved) – Lower Back Pain: Radiating pain – Pain During Ovulation: At mid-cycle

Severity Spectrum: – Mild: Occasional discomfort – Moderate: Regular pain requiring management – Severe: Debilitating pain affecting daily life

Other Symptoms: – Heavy or irregular menstrual bleeding – Infertility or subfertility – Fatigue – Bloating – Nausea – Diarrhea or constipation (if bowel involved) – Emotional symptoms (depression, anxiety)

Important Note: Symptom severity doesn’t correlate with disease severity. Some women with extensive disease have minimal symptoms, while others with mild disease have severe pain.

Causes and Risk Factors

Proposed Causes:

  1. Retrograde Menstruation Theory (Most Accepted): – Menstrual tissue flows backward through fallopian tubes – Implants on pelvic organs – Explains why endometriosis is most common in pelvis
  2. Tissue Injury and Repair: – Cyclical menstrual bleeding causes inflammation – Tissue damage and repair cycles – Stem cells develop into endometrial-like tissue
  3. Coelomic Metaplasia: – Peritoneal tissue transforms into endometrial tissue – Occurs in response to inflammation or injury
  4. Bone Marrow-Derived Cells: – Bone marrow cells migrate to ectopic sites – Differentiate into endometrial tissue
  5. Vascular and Lymphatic Invasion: – Endometrial cells invade blood vessels – Spread systemically – Implant in distant sites

Risk Factors: – Early menarche (first period) – Late menopause – Prolonged menstruation – Short menstrual cycles – Heavy menstrual bleeding – Family history (5-7% of first-degree relatives affected) – Never having been pregnant – Certain genetic variants – Immune system dysfunction – Estrogen and progesterone resistance

Diagnosis of Endometriosis

Clinical Assessment: – Detailed history of pain and symptoms – Menstrual history – Fertility history – Symptom pattern

Physical Examination: – Pelvic examination may reveal tenderness – Nodules palpable in some cases – Often normal despite disease presence

Imaging Studies:

Transvaginal Ultrasound (Most Useful): – Visualizes ovarian endometriosis – Detects deep infiltrating endometriosis – Non-invasive, no radiation – Sensitivity: 80-90% for ovarian lesions – Lower sensitivity for peritoneal disease

MRI: – Excellent for deep infiltrating endometriosis – Assesses bowel and bladder involvement – Higher cost, longer duration – Useful for surgical planning

CT Scan: – Limited usefulness – Radiation exposure

Gold Standard Diagnosis:Laparoscopy with Biopsy – Direct visualization of lesions – Tissue confirmation (histology) – Often therapeutic (lesions removed) – Allows staging – Requires anesthesia and surgery

Blood Markers: – CA-125: Elevated but not specific – Other markers: Research stage – Not reliable for diagnosis

Treatment Options

Conservative Treatment (First-Line):

Pain Management:NSAIDs: Ibuprofen, naproxen for menstrual pain – Take before period starts for better effectiveness – Success rate: 50-60%

Hormonal Therapy (Reduces or Stops Menstruation):

  1. Combined Oral Contraceptives: – Decreases menstrual flow – Reduces pain symptoms – Success rate: 50-60% – Can take continuously (skip placebo pills) – No fertility impact (restores once stopped)
  2. Progestin-Only Pills (Minipill): – Thins endometrium – Reduces bleeding and pain – Success rate: 60-70% – Can take continuously
  3. Hormonal IUD (Mirena): – Releases progestin directly to uterus – 5-year duration – Very effective (70-80% success) – Reduces heavy bleeding – Maintains fertility (reversible) – No systemic hormones
  4. Depot Medroxyprogesterone (Depo-Provera): – Injectable progestin every 3 months – Success rate: 60-70% – Causes temporary amenorrhea (no periods) – Reversible (fertility restores in 9-12 months)
  5. Oral Progestins: – Norethindrone, dienogest – Take daily or cyclically – Success rate: 50-60%

GnRH Agonists (Advanced Hormonal Therapy): – Suppresses ovarian hormones – Induces temporary menopause state – Very effective (80-90% pain relief) – Used for 3-6 months maximum – Side effects: Hot flashes, mood changes – Add-back therapy (low-dose estrogen/progestin) to minimize side effects – Expensive – Reserved for severe cases or failed previous treatment

Surgical Treatment:

Diagnostic/Therapeutic Laparoscopy: – Gold standard for diagnosis – Allows lesion removal/ablation – Success rate: 50-80% pain relief – Relief may be temporary (need long-term management) – Can assess severity and guide treatment – Allows adhesiolysis (adhesion removal)

Conservative Surgery (Preserve Uterus and Ovaries): – Remove or ablate lesions – Lyse adhesions – Best for women wanting fertility preservation – Recurrence rate: 20-40% at 5 years

Hysterectomy (Definitive Surgery): – Removes uterus – May remove ovaries – Most effective (95% pain relief if ovaries removed) – Eliminates fertility – Reserved for women complete with childbearing – Recurrence possible if ovaries retained

Combined Medical + Surgical Approach: – Most effective strategy – Surgery to remove lesions/adhesions – Hormonal therapy afterward to prevent recurrence – Offers both immediate pain relief and long-term management

Managing Endometriosis Long-Term

Fertility Considerations: – Endometriosis affects 30-40% of infertile women – Treatment depends on stage and desire for pregnancy – Options: Expectant management, stimulated cycles, IVF – Success rates vary (30-50% per cycle for IVF) – Earlier treatment may improve fertility outcomes

Lifestyle Modifications: – Regular exercise (reduces pain, improves mood) – Heat therapy (heating pads for pain relief) – Stress management – Dietary modifications (anti-inflammatory foods) – Avoid caffeine, alcohol – Adequate sleep – Support groups and counseling

Symptom Management: – Maintain pain diary – Communicate with doctor about symptoms – Adjust treatment as needed – Regular follow-up

What Dr. Anju Bala Recommends

“Endometriosis is a chronic condition requiring long-term management. The goal is maximum symptom control with minimum side effects. This often requires combining multiple approaches—medical, surgical, and lifestyle modifications. Every woman’s situation is unique, so we develop personalized treatment plans.”

When to Seek Treatment

Consult Dr. Anju Bala For: – Severe menstrual pain not improving with NSAIDs – Chronic pelvic pain – Pain during intercourse – Infertility concerns – Heavy or irregular bleeding – Suspected endometriosis – Failed medical treatment

Why Choose North Delhi Uro & Gynae Clinic?

  • Experienced gynaecologist in North Delhi (Dr. Anju Bala)
  • Comprehensive diagnostic approach
  • Multiple treatment options
  • Surgical expertise (laparoscopy)
  • Compassionate care for chronic condition
  • Long-term follow-up and support

Endometriosis is a chronic condition, but it’s treatable. With proper diagnosis, comprehensive treatment planning, and long-term management, most women achieve significant pain relief and maintain quality of life.

Don’t suffer. Effective treatment is available.

Contact North Delhi Uro & Gynae Clinic: – Address: C-5, Model Town 3, New Delhi 110009 – Phone: 9910118030 – Doctor: Dr. Anju Bala (MBBS, MD, DNB) – Obstetrician & Gynaecologist

Reclaim your quality of life.

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