Carcinoma Penis

Q 1. What is penis cancer?

A. Cancer is abnormal cell growth in the skin or organ tissue. When this cell growth starts in the penis, it is called penis cancer or penile cancer.

It is more common in men older than age 40, but younger men can get it. Most penis cancer patients are 60–70 years old.

Carcinoma Penis

Q 2. What are the symptoms of penis cancer?

A. Penis cancer usually appears on the penis skin. It can look like a rash or a sore that doesn’t heal. You might notice bleeding or a bad smell. If you have a foreskin, it might change in appearance or may have become too tight to pull back. If you notice these symptoms, ask your doctor if you have penis cancer or another medical problem. Problems with your penis might make you feel embarrassed or worried. Your doctor will be used to talking about these kinds of problems. Don’t wait to see your doctor.

  • If it is cancer, early treatment is better.
  • If the symptoms are caused by another medical problem, like a sexually transmitted disease, treatment can help resolve it quickly.
  • If penis cancer is not treated right away, it can continue to grow deeper into tissue or spread to other organs. This is called advanced penis cancer.

Signs of advanced penis cancer:

  • Swollen lymph node in the groin (may feel like a lump)
  • Fatigue
  • Weight loss
  • Bone pain
  • Pain in the abdomen

Q 3. What are the risk factors for cancer penis?

A. The exact cause of penis cancer is not known. Men with certain conditions have a higher risk of getting penis cancer:

  • A foreskin
  • A tight foreskin that cannot be pulled back over the head of the penis (phimosis)
  • Human papilloma virus (HPV) infection, usually of the foreskin
  • A condition called lichen sclerosis, which only affects men with a foreskin and causes inflammation of the penis
  • Long-term irritation or inflammation of the penis
  • Treatment of a severe skin condition using chemotherapy and ultraviolet light (PUVA)

Men who have had the foreskin removed surgically (circumcision) have the lowest risk of getting penis cancer. Circumcision prevents phimosis and lichen sclerosis and makes men less likely to get HPV.

Other risk factors for penis cancer include:

  • Using tobacco products
  • Age 60 or older
  • Having many sexual partners
  • Young age at first intercourse

Female sexual partners of men with penis cancer do not have a higher risk of cervical cancer from HPV.

Q 4. What are the types of penis cancer?

A. The type of penis cancer depends on the type of cell that started growing. More than 90% of penis cancer starts in skin cells called squamous cells. Penis cancer develops mostly on the skin at the glans (head) or in the inner layer of the foreskin.

Carcinoma in situ (CIS) is a type of squamous cell cancer that affects only the cells in the skin of the penis and has not grown any deeper.

Penis cancer can arise from different cell types. The prognosis is usually dependent on the stage of the disease. But some specific cell types are more aggressive, and others are never life-threatening.

Q 5. How do you diagnose Cancer Penis?

A. Your doctor will talk with you about your symptoms and medical history. The doctor will do a physical exam of your penis and check the lymph nodes in your groin for swelling. Tests might be arranged if your doctor thinks you could have penis cancer:

  • Blood might be drawn for test for certain proteins linked to penis cancer.
  • Fluid might be drawn from swollen lymph nodes for examination under a microscope (biopsy) to check for cancer cells.
  • A small piece of abnormal skin might be removed for biopsy to look for cancer cells.
  • Imaging tests like ultrasound, MRI, or CT scan can show what’s happening inside the tissue or organ.
  • A sentinel node biopsy marks the lymph nodes closest to the penis with a radioactive fluid, and then the lymph nodes are removed and examined for cancer cells; if cancer is found, more lymph nodes might have to be removed to prevent spread.

Q 6. How do you classify cancer penis? How does it spread?

A. Penis cancer is classified by stage based on the aggressiveness of the cancer cells. Staging is a standard way to describe whether the cancer has spread. The kind of treatment you receive will depend on the stage. For staging, the Tumour Node Metastasis (TNM) classification is used. This classification system describes the penile tumour (T), spread to lymph nodes (N) and spread to other tissues or organs in the body (M).

Carcinoma Penis
Pattern of spread: A growth of abnormal cells forms a tumour. The first tumour on the penis, called primary tumour, can spread (metastasize) to other sites and form new tumours there (metastases). Penis cancer spreads gradually. In most cases, the tumour spreads first to the lymph nodes in the groin (inguinal) and then to the pelvic lymph nodes in the abdomen, both called regional spread. After that, new tumours can form in the lungs, bones, skin, or other organs. This is the usual pattern of spread, but exceptions may occur.

Carcinoma PenisCarcinoma Penis

Q 7. How do you treat cancer penis?

A. Penis cancer treatment involves removing the primary tumour and managing the lymph nodes and other tumours. The type of treatment depends on how deep the tumour has grown into the penis tissue. This is based on cancer stage, as discussed under Classification.

Treatment of Carcinoma in situ: Various options exist to treat penis CIS. The goal is to keep the penis looking healthy and working normally:

  • Skin cream to put on the affected skin may include medicines to treat cancer (chemotherapy).
  • Laser therapy to remove affected skin
  • Cryotherapy to freeze and remove affected skin
  • Surgery called “glans resurfacing” to remove the top layers of skin from the head of the penis and resurface it with skin from another area of the body (skin graft)

Treatment of Penis tumour: Treatment of the penis tumour depends on the size of the tumour and the tissues the tumour has grown into. Penis tumours are mostly treated with surgery.

  • Circumcision (removing the foreskin) if penis cancer is only in the foreskin
  • Laser therapy
  • Glans resurfacing to remove the top layers of skin from the head of the penis and resurface it with a skin graft
  • Glansectomy
  • Removal of part of the penis where the tumour is growing (partial penectomy)
  • Removal of the whole penis (total penectomy)
  • Radiation therapy to the penis to help kill cancer cells
  • Chemotherapy to help shrink the tumour (usually only for T4 tumours that are too large to be removed with surgery)

If the whole penis is removed, a new opening must be created surgically to carry urine out of the body. This opening is usually placed on the perineum-the space between your scrotum and anus-between your legs.

Treatment of the lymph nodes:

  • If the cancer has spread to one or more lymph nodes, the lymph nodes will be treated with surgery, radiation therapy or chemotherapy. Removal of affected lymph nodes in the groin or abdomen
  • Radiation therapy to help kill cancer cells
  • Chemotherapy to help kill cancer cells
  • Your doctor may also choose to give more than one treatment. For example, radiation before or after removal of the lymph nodes.

Treatment of distant metastases:
When the cancer has spread to other tissues than lymph nodes in your body, you are very unlikely to be cured by therapy. The goal of treatment is to control or stop the cancer and relieve symptoms via:

  • Radiation therapy
  • Chemotherapy

Q 8. What is penectomy?

A. If a tumour has grown into surrounding tissue, removing it surgically is the best chance of cure. If the tumour is in your penis tissue, some or all of your penis might need to be removed to get rid of the cancer.

  • If only the end of the penis will be removed, the surgery is called a partial penectomy.

Carcinoma Penis

  • Removal of just the head of the penis is called a glansectomy. The surgeon will remove the end but leave as much of your penis as possible. A new end will be built using a skin graft from your thigh. If possible, your penis will be long enough for you to urinate standing up.

Carcinoma Penis

 

  • Total penectomy is removal of the whole penis. This includes the shaft and the root, which is inside your body. Also, a new opening may be created surgically to carry urine out of the body. This opening is usually placed on the perineum-the space between your scrotum and anus-between your legs.

Q 9. What is the Follow-up?

A. After penis cancer treatment, your doctor will schedule you for regular visits to check your progress. Visits will be more frequent in the first year or two after surgery and then less
often over time.

A physical exam will look at your penis and check for new signs of cancer (recurrence).

You should examine your penis and lymph nodes regularly (self-examination). Get to know what is normal for you. Contact your doctor if you notice changes.

Q 10. How will this affect my sex life?

A. A satisfying sex life is part of your quality of life after penis surgery. Your doctor will consider this in recommending treatment. And surgery will preserve as much of your penis as possible. The type of treatment you have will affect your sex life after penis cancer.

Men treated for CIS and stage 1 penis cancer can usually continue their sex lives as before.

Partial penectomy for stage 2 or 3 penis cancer will preserve as much of the penis as possible. Many men are still able to have an erection and perform penetrative sex after surgery.

The whole penis may be removed to treat stage 3 or 4 penis cancer. You can have a fulfilling sex life after total penectomy, but it will likely be different. Your scrotum, testicles, and perineum will still be sensitive, and orgasm may be possible.

Explore new ways to be sexual with your partner. An erection might be possible after penis reconstruction surgery. It will depend on whether your nerves and blood supply can be reconnected. Ask your surgeon about what results are possible.

Q 11. Can this cancer recur after surgery?

A. Sometimes penis cancer comes back after treatment is complete. This is called recurrence. Your doctor will check for recurrence during your follow-up visits. Regular self-examination will also help catch recurrence early.

Treatment is based on your previous type of treatment and the location of the new cancer:

  • On the penis: Surgery to remove cancer cells, possibly followed by radiation therapy.
  • In the lymph nodes: Surgery to remove the lymph nodes and/or radiation therapy or chemotherapy.
  • In other tissues or organs: chemotherapy or radiation therapy to shrink tumours.